Книга
СТВОЛОВЫЕ КЛЕТКИ: БИОЛОГО-ФИЗИОЛОГИЧЕСКИЕ ЗАКОНОМЕРНОСТИ РАЗВИТИЯ, ФУНКЦИИ И МЕХАНИЗМЫ
В монографии приведены основные биолого-физиологические закономерности развития, функции, механизмы и виды дифференцировки стволовых клеток, их способность к размножению и генерации потомства на уровне популяции. Дается краткое обоснование двух принципиально разных типов стволовых клеток: плюрипотентных, которые существуют только in vitro, и тканевых, существующих in vivo в послеродовом организме. Показано, что плюрипотентные клетки могут приводить к появлению широкого спектра типов клеток, в отличие от тканевых, которые в нормальных условиях не генерируют клетки, характерные для других типов тканей. Представлены этапы развития плюрипотентных стволовых клеток. Обсуждается роль ключевых маркеров плюрипотентности и факт того, что самым надежным способом идентификации стволовых клеток является определение их фенотипа in vivo. Это свидетельствует о том, что стволовые клетки не несут универсального молекулярного маркера, позволяющего дифференцировать стволовые клетки от нестволовых. Рассмотрены объекты и современные методы редактирования генома. Охарактеризована иммунная система прокариот и их защитные механизмы, препятствующие целевому редактированию генома в интересах исследователя. Описаны фазы развития эмбриона, начиная с формирования гамет и зародышевых линий, различия в отборе зародышевых и соматических клеток, рассматривается образование истинных зародышевых клеток, их типы, факторы, обеспечивающие их дифференцировку и миграцию. Представлены проб лемные и перспективные сведения по использованию стволовых клеток в трансплан тологии и другие не менее интересные вопросы, касающиеся стволовых клеток. Монография предназначена биологам, физиологам, врачам, научным работникам, будет полезна преподавателям, аспирантам и студентам биологических и медицинских факультетов университетов, академий и институтов, а также широкому кругу читателей.
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